According to an interesting study on estradiol intake, if estradiol is taken within six years of menopause, real benefits can be obtained to combat atherosclerosis and other pathologies such as the accumulation of plaque in the walls of the arteries. However, if the intake of the same oestradiol begins 10 years after the onset of menopause, there are no equal benefits.
The preliminary research was presented during a session of the American Heart Association 2020. The main author of the study is Roksana Karim, professor of preventive clinical medicine at the University of Southern California Medical School, Los Angeles.
According to the researcher, the results she obtained from her study show that taking oestradiol in time during menopause can help reduce atherosclerosis and reduce cholesterol buildup in the veins.
Atherosclerosis is one of the most common diseases that cause heart disease and its main feature is the accumulation of cholesterol in the walls of the veins.
To arrive at these results, the researcher carried out a study on 643 healthy post-menopausal women. The latter were divided into four groups: the first and second group consisted of women who received 1 mg of estradiol per day (first group) or a placebo pill (second group) within six years of the onset of menopause.
The members of the other two groups took the same thing (oestradiol for the third group and placebo pill for the fourth group) but 10 years or more after the onset of menopause. All components took either estradiol or the placebo pill every day for an average of five years.
In the end, the researchers found that the rate of advancement of atherosclerosis among the members of the first group was half as low as the women in the first group who took the placebo pill.
They also found that oestradiol had no effect in women in the second group, i.e. those who had started taking oestradiol 10 years or more after the onset of menopause. Patients in the third and fourth groups saw atherosclerosis progress in a similar way.
These results “show that starting oestradiol immediately after the onset of menopause may result in lower cholesterol deposition in the arteries than women who start [taking] oestradiol much later,” Karim reports.
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