Schizophrenia: 10 new genes involved have been identified

In one of the largest studies on DNA sequencing associated with schizophrenia, a group of researchers led by Tarjinder Singh discovered 10 new genes involved in the development of this disease using a method called “whole exome sequencing.” The researchers used the genetic data of more than 125,000 people to obtain different information about the genetic basis of the same schizophrenia. The research results were then presented at the annual meeting of the American Society of Human Genetics 2019 in Houston.

One of the reasons why researchers have used DNA sequencing to obtain information about schizophrenia is that there has been limited progress in the development of new schizophrenia drugs over the past 50 years. However, the use of new genetic techniques has proved very useful in many areas in recent years, and researchers themselves believe that useful results can be obtained to discover the mechanisms of schizophrenia.

The latter is one of the psychiatric disorders not yet fully understood. However, it is believed that its development can be accelerated by disorders of certain genes encoding certain proteins.
It is precisely because these are rare genetic changes that researchers have used a very large number of people. Of the 125,000 people tested, 25,000 were diagnosed with schizophrenia. People came from all five continents.

After the analysis, the researchers identified 10 genes that, once they stopped functioning, caused an increased risk of schizophrenia, according to Singh himself in the press release. Two of these 10 genes encode glutamate receptors, suggesting that these receptors may be a target for future schizophrenia therapies.