Sleep deprivation can lead to very negative consequences for the synaptic activities of the brain, especially plasticity, which are performed thanks to the group of key proteins.
In two separate studies, researchers Sara Noya and colleagues and Franziska Brüning and colleagues show how much more important sleep is than ever before in terms of synaptic activity and thus the risk of cognitive impairment.
Noya and colleagues evaluated the circadian rhythm of synaptic messenger RNA (mRNA) and the amount of protein over 24 hours in experiments on mice and found that this model was very different in sleepless people.
Brüning and colleagues investigated the relationships between sleep-wake cycles, sleep pressure and synaptic phosphoteomics, again in experiments on mice, and discovered that sleep deprivation led to abrupt interruptions of daily cycles in almost 1000 phosphoproteins.
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